Ramkrishna Mitra

This study shows p38α MAPK links oncogenic APC/β-catenin/TCF signaling with the GUCY2C tumor-suppressor axis in colorectal cancer by regulating hormone expression and signaling pathways.

This study shows that activating SIRT6 with MDL-800 improves intervertebral disc health in aged mice by enhancing autophagy, reducing senescence, and improving matrix quality.

This study shows that SIRT6 loss in mice leads to intervertebral disc degeneration by promoting senescence and SASP through changes in histone modifications, DNA accessibility, and autophagy.

The paper identifies 30 high-confidence lncRNAs critical for cancer proliferation by integrating CRISPR data with multi-omics, showing their role in cell cycle regulation and patient survival.