Molecular BiologybioRxivPreprint
SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status
Pranay L. Ramteke, Bahiyah Watson, Mallory Toci…·Makarand V. Risbud
This study shows that SIRT6 loss in mice leads to intervertebral disc degeneration by promoting senescence and SASP through changes in histone modifications, DNA accessibility, and autophagy.
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