BiochemistrybioRxivPreprint
SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine
Pranay L. Ramteke, Bahiyah Watson, Sanjana Jagannath…·Makarand V. Risbud
This study shows that activating SIRT6 with MDL-800 improves intervertebral disc health in aged mice by enhancing autophagy, reducing senescence, and improving matrix quality.
DOI 10.64898/2026.03.03.709336