Pranay L. Ramteke

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

This study shows that activating SIRT6 with MDL-800 improves intervertebral disc health in aged mice by enhancing autophagy, reducing senescence, and improving matrix quality.

Neuroimmune changes underscore pain-associated behaviors and disc herniations in SM/J mice

This study identifies SM/J mice as a model for spontaneous disc herniations and shows neuroimmune changes drive chronic discogenic pain.

SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status

This study shows that SIRT6 loss in mice leads to intervertebral disc degeneration by promoting senescence and SASP through changes in histone modifications, DNA accessibility, and autophagy.