Ruteja A. Barve

CompBio and MIRaS : A Multi-omic Analysis Platform Built on a Memory-Based Intelligence Engine

The paper introduces CompBio, a multi-omic analysis platform using MIRaS, a memory-based intelligence engine, to analyze omics data without relying on human-curated knowledgebases, producing traceable and statistically significant results.

SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine

This study shows that activating SIRT6 with MDL-800 improves intervertebral disc health in aged mice by enhancing autophagy, reducing senescence, and improving matrix quality.

SnakeAltPromoter Facilitates Differential Alternative Promoter Analysis

SnakeAltPromoter provides a reproducible framework for differential alternative promoter analysis using RNA-seq, benchmarked against CAGE data and scalable for large datasets.

SIRT6 loss causes intervertebral disc degeneration in mice by promoting senescence and SASP status

This study shows that SIRT6 loss in mice leads to intervertebral disc degeneration by promoting senescence and SASP through changes in histone modifications, DNA accessibility, and autophagy.

Single cell RNAseq uncovers a robust transcriptional response to morphine by oligodendrocytes

This study identifies morphine-induced gene expression changes in oligodendrocytes using single-cell RNA sequencing in mice, highlighting pathways related to myelination.