Ye Zhan

This study shows Prmt5 regulates gene expression and chromatin organization during adipogenesis by modulating TAD boundaries and chromatin loop anchors.

The paper generates chromosome-level reference genomes for two C. briggsae strains, improving genomic resources for comparative genomics in the Caenorhabditis genus.

The paper presents a chromosome-level genome assembly of the Atlantic silverside and reports high heterozygosity and extensive structural variation linked to local adaptation.

The paper assembles the genome of Symbiodinium microadriaticum using Hi-C and describes its unique chromosomal structure and organization.

The paper evaluates reproducibility and quality measures for Hi-C data using real and simulated datasets, showing that specialized methods outperform simple correlation analysis.

This study shows that SmcHD1 prevents TAD formation on the inactive X chromosome by altering chromatin structure and epigenetic marks.

This paper presents an integrative framework to detect structural variants in cancer genomes using multiple methods and finds that non-coding structural variation significantly impacts genome function in cancer cells.

The paper investigates the HoxD cluster's role as a dynamic TAD boundary in limb development, showing its resilience and ability to maintain regulatory segregation.