Phosphatidylserine (PS)-targeting chimeric Interferon (IFN) fusion proteins for anti-tumor applications
Varsha Gadiyar, Viralkumar Davra, Rachael Pulica, Trevor Frederick, Christopher Varsanyi, Ahmed Aquib, Ziren Wang, Smirnov Sv, Samhita Bapat, David C. Calianese, Alok Kumar Choudhary, Sergei V. Kotenko, Raymond B. Birge
This paper develops PS-targeting chimeric IFN fusion proteins that enhance anti-tumor activities by combining IFN-β and IFN-λ with the PS-binding Gas6 domain.
bioRxiv · Jan 24, 2025 · PreprintCancer Biology