Alok Kumar Choudhary

Novel human monoclonal antibodies with enhanced sensitivity for lipoarabinomannan antigens present in urines of TB patients

Converting human antibody A194-01 from IgG1 to IgM broadens glycan recognition and boosts urinary lipoarabinomannan detection, and RU95-C1, a mannan-targeting antibody, works as a capture partner.

Phospholipid Scramblases TMEM16F and Xkr8 regulate distinct features of Phosphatidylserine (PS) externalization and immune regulation in the tumor microenvironment to regulate tumor growth

This study shows that Xkr8 and TMEM16F regulate distinct PS externalization mechanisms in the tumor microenvironment, influencing immune evasion and tumor growth.

Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction.

This study identifies protective antibodies against Mycobacterium tuberculosis and shows that their Fc-effector function and Fab domains collaborate to restrict infection through immune cell reorganization.

Phosphatidylserine (PS)-targeting chimeric Interferon (IFN) fusion proteins for anti-tumor applications

This paper develops PS-targeting chimeric IFN fusion proteins that enhance anti-tumor activities by combining IFN-β and IFN-λ with the PS-binding Gas6 domain.