Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks
Qilin Long, Kamal Ajit, Kateřina Šedová, Vojtech Haluza, Richard Štefl, Sadat Dokaneheifard, Felipe Beckedorff, Monica G Valencia, Marek Šebesta, Ramin Shiekhattar, Monika Gullerová
The paper identifies the tetrameric INTS6-SOSS1 complex as essential for DNA:RNA hybrid autoregulation at double-strand breaks, facilitating DNA repair through PP2A recruitment and DARTs prevention.
Nucleic Acids Research · Oct 8, 2024Peer-reviewedMolecular Biology