Balancing Activation and Repression: CoREST-p300 Antagonism Controls Retinoic Acid-Driven Differentiation in AML
Mina Masoumeh Tayari, Helena Gomes Dos Santos, Sadat Dokaneheifard…·Ramin Shiekhattar
The paper shows that Corin, a dual LSD1/CoREST inhibitor, synergizes with ATRA to induce differentiation and apoptosis in AML by disrupting CoREST-RAR/RXR complexes and recruiting p300.