Author

Kateřina Šedová

Masaryk UniversityORCID 0000-0001-6053-1100Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Marek ŠebestaiD· 3 shared Monika GullerováiD· 2 shared Qilin LongiD· 2 shared Richard ŠtefliD· 2 shared Vojtech Haluza· 2 shared Adele AlagiaiD· 1 shared Felipe BeckedorffiD· 1 shared Josef HouseriD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersMolecular Biology

Marek ŠebestaORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintJan 22, 2025

Distinct Mechanisms of Recognition of Phosphorylated RNAPII C-Terminal Domain by BRCT Repeats of the BRCA1-BARD1 Complex: Insights from Structural and Functional Analyses

Veronika Klapstova, Kateřina Šedová, Josef Houser, Marek Šebesta

This study investigates how the BRCA1-BARD1 complex interacts with phosphorylated RNAPII CTD through BRCT repeats, revealing its role in RNAPII condensation and transcription-DNA repair coordination.

DOI 10.1101/2025.01.22.634233

proteomicsexperimental assay

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Molecular BiologyNucleic Acids ResearchPeer-reviewedOct 8, 2024

Tetrameric INTS6-SOSS1 complex facilitates DNA:RNA hybrid autoregulation at double-strand breaks

Qilin Long, Kamal Ajit, Kateřina Šedová…·Monika Gullerová

The paper identifies the tetrameric INTS6-SOSS1 complex as essential for DNA:RNA hybrid autoregulation at double-strand breaks, facilitating DNA repair through PP2A recruitment and DARTs prevention.

11 citations

experimental assay

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Molecular BiologyCell ReportsPeer-reviewedNov 29, 2023

Phosphorylated trimeric SOSS1 complex and RNA polymerase II trigger liquid-liquid phase separation at double-strand breaks

Qilin Long, Marek Šebesta, Kateřina Šedová…·Monika Gullerová

The paper shows that the SOSS1 complex and RNA polymerase II form phase-separated compartments at double-strand breaks to facilitate DNA repair.

23 citations

humanDNA methylation

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