Sequence-to-function modeling uncovers the context-specific grammar of Drosophila chromatin insulation
Brendan Wang, Gabriel A. Dolsten, Wenfan Ke, W Zhang, Anton V. Persikov, Xinyang Bing, Xiao Li, Miki Fujioka, James B. Jaynes, Amina Kurbidaeva, Tiffany Park, Mona Singh, Michael S. Levine, Paul D. Schedl, Yuri Pritykin
The paper introduces Domino, a deep learning framework that models sequence-to-function relationships to uncover the context-specific grammar of Drosophila chromatin insulation.
bioRxiv · Jun 19, 2026 · PreprintGenomics