This study shows that Lactiplantibacillus plantarum VB165 reduces metabolic disorders in insulin-resistant mice by improving glucose tolerance, reducing inflammation, and modulating gut microbiota.

bioRxiv · Mar 30, 2026 · PreprintMicrobiology

Acquired stress resilience through bacteria-to-nematode horizontal gene transfer

Taruna Pandey, Chinmay A. Kalluraya, Bingying Wang, Ting Xu, Xinya Huang, Shouhong Guang, Matthew D. Daugherty, K. Dengke

The paper identifies a nematode gene acquired via horizontal gene transfer from bacteria that enhances stress resilience by enabling L-rhamnose biosynthesis for cuticle integrity.

bioRxiv · Aug 20, 2023 · PreprintGenetics

A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans

Ting Xu, Shimiao Liao, Chengming Zhu, Qile Jin, Demin Xu, Chuanhai Fu, Xiangyang Chen, Xuezhu Feng, Shouhong Guang

The paper identifies a ZTF-7/RPS-2 complex involved in C. elegans' response to cold-warm temperature changes by regulating RNA exosome localization.

bioRxiv · Oct 24, 2022 · PreprintGenetics

Co-surveillance of ribosomal RNA by the exosome complex and nucleolar RNAi in C. elegans

Shimiao Liao, Xiangyang Chen, Ting Xu, Qile Jin, Zongxiu Xu, Demin Xu, Xufei Zhou, Chengming Zhu, Shouhong Guang, Xuezhu Feng

The paper identifies factors involved in risiRNA generation in C. elegans and shows their role in rRNA surveillance through exosome and nucleolar RNAi mechanisms.

bioRxiv · Nov 23, 2020 · PreprintGenomics

A cytoplasmic Argonaute protein promotes the inheritance of RNAi

Fei Xu, Xuezhu Feng, Xiangyang Chen, Chenchun Weng, Qi Yan, Ting Xu, Minjie Hong, Shouhong Guang

The paper identifies WAGO-4, a cytoplasmic Argonaute protein, as essential for the inheritance of RNAi in C. elegans, showing its role in translocating to the germline and binding 22G-RNAs.

Cell Reports · May 1, 2018Peer-reviewedGenetics