Author

W. A. Jefferies

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

C. G. Pfeifer· 3 shared H. Arora· 2 shared K. B. Choi· 2 shared L. Munro· 2 shared C.-J. Lu· 1 shared E. J. Wherry· 1 shared F. Fenninger· 1 shared K. C. O'Boyle· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersImmunology

C. G. Pfeifer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An ATP-Binding Cassette Transporter Gene Links Innate and Adaptive Immune Responses

S. Wilcox, H. Arora, K. B. Choi, S. Kari, L. Munro, C. G. Pfeifer, W. A. Jefferies

This study identifies ABCF1 as a critical link between innate and adaptive immunity by regulating OAS1 and RNaseL activity, influencing antiviral responses to SARS-CoV-2 and VSV.

bioRxiv · Dec 31, 2023 · PreprintImmunology

Phagocytosis in macrophages is regulated by the ATP-binding cassette family gene ABCF1

H. Arora, K. B. Choi, L. Munro, C. G. Pfeifer, W. A. Jefferies

This study identifies ABCF1 as a regulator of phagocytosis in macrophages through its role in signaling pathways involving Src family kinases and SYK.

bioRxiv · Sep 5, 2023 · PreprintImmunology

Nanomule Peptide-siRNA Conjugate that Traverses the Intact Blood Brain Barrier and Attenuates Stroke

W. A. Jefferies

The paper develops a peptide-siRNA conjugate that crosses the blood-brain barrier and reduces ischemic stroke severity by targeting NOX4.

bioRxiv · Dec 10, 2019 · PreprintPathology

Mutation of an L-Type Calcium Channel Gene Leads to a Novel Human Primary Cellular Immunodeficiency

F. Fenninger, S. R. Stanwood, C.-J. Lu, C. G. Pfeifer, O. Khan, N. D. Romberg, R. Herati, E. J. Wherry, K. C. O'Boyle, S. E. Henrickson, K. Maurer, M. A. Ruffner, W. A. Jefferies, K. E. Sullivan

This study identifies a mutation in the Cav1.4 gene causing a primary immunodeficiency with immune dysfunction and recurrent infections.

bioRxiv · Dec 4, 2019 · PreprintImmunology