Identifying Dihydropyrimidine Dehydrogenase as a Novel Regulator of Hepatic Steatosis
K. E. Sullivan, S. Kumar, Y. Zhang, E. de Koning, J. Yuan, F. Fan
This study identifies DPYD as a regulator of hepatic steatosis through in vitro experiments showing its inhibition reduces lipid accumulation and its gain-of-function mutation increases lipid burden.
bioRxiv · Mar 4, 2021 · PreprintCell Biology