W. A. van der Donk

This study discovers a new class of macrocyclic peptides by mining genomes for biosynthetic gene clusters, revealing novel enzymatic modifications involving a cytochrome P450 and other enzymes.

The paper characterizes six gut-derived nisin-like lantibiotics, evaluates their antimicrobial activity against pathogens and commensals, and identifies key residues affecting their activity.

This study identifies a new reaction catalyzed by DUF692, a posttranslational modification enzyme, revealing its role in forming a macrocycle and other chemical modifications in a RiPP natural product.