SAVED by a toxin: Structure and function of the CRISPR Lon protease.
C. Rouillon, N. Schneberger, H. Chi, M. F. Peter, M. Geyer, W. Boenigk, R. Seifert, M. F. White, G. Hagelueken
The paper reports the crystal structure of CRISPR-Lon, a protein that activates by binding cA4 and cleaves CRISPR-T to release a nuclease-like fragment.
bioRxiv · Dec 6, 2021Biochemistry