G. Ha

The hyperphosphorylation of SARS-CoV-2s nucleocapsid protein by GSK-3 involves a complex and redundant priming mechanism

This study reveals that SARS-CoV-2 nucleocapsid protein hyperphosphorylation by GSK-3 involves a complex, cooperative priming mechanism rather than simple sequential phosphorylation.

Measuring and modeling the dynamics of mitotic error correction

The paper quantifies mitotic error correction dynamics in human cells and validates a model explaining error reduction and anaphase timing.

Dual mechanism of kinetochore microtubule detachment

This paper investigates how kinetochore microtubules detach by combining experimental measurements and modeling, revealing a dual mechanism involving NDC80 complex binding energetics and microtubule catastrophe.

Nucleosome patterns in circulating tumor DNA reveal transcriptional regulation of advanced prostate cancer phenotypes

This paper identifies nucleosome patterns in ctDNA that distinguish advanced prostate cancer phenotypes, achieving high accuracy in classification using a prediction model.

DNA-based copy number analysis confirms genomic evolution of PDX models

The paper reassesses genomic evolution in PDX models using DNA-based copy number profiles, finding significant genomic divergence between primary tumors and PDXs across passages.

A coarse-grained NADH redox model enables inference of subcellular metabolic fluxes from fluorescence lifetime imaging

This paper develops a coarse-grained NADH redox model to infer subcellular mitochondrial metabolic fluxes from fluorescence lifetime imaging in mouse oocytes and human cells.

Patient-derived xenografts undergo murine-specific tumor evolution

This study shows that PDX tumors acquire new genomic changes over passages, differ from human tumors, and affect drug responses.