W. I. Weis

The co-receptor Tetraspanin12 directly captures Norrin to promote ligand-specific β-catenin signaling

This study identifies Tetraspanin12 as a co-receptor that directly binds Norrin to enhance its signaling through the Wnt/β-catenin pathway by capturing Norrin before it interacts with Fzd4.

Multi-level force-dependent allosteric enhancement of αE-catenin binding to F-actin by vinculin

This study investigates how multiple cadherin-catenin complexes interact with F-actin under force and how vinculin enhances this interaction, revealing cooperative mechanisms that strengthen cell-cell junctions.

Mechanism of the cadherin-catenin F-actin catch bond interaction

This study identifies the E-cadherin/{beta}-catenin/E-catenin complex's catch bond mechanism with F-actin, showing the ABD's role in force-dependent binding and its impact on cytoskeletal linkages.

Distinct autoinhibitory mechanisms regulate vinculin binding by alpha-T-catenin and alpha-E-catenin

This study identifies distinct autoinhibitory mechanisms in T-catenin and E-catenin regulating vinculin binding, showing that T-catenin's N-terminus maintains M-region autoinhibition.

Structural basis of αE-catenin-F-actin catch bond behavior

The paper describes the cryo-EM structure of E-catenin's actin-binding domain and explains how mechanical force affects its binding to F-actin, revealing the mechanism of catch bond behavior.

Lattice micropatterning for cryo-electron tomography studies of cell-cell contacts

This study uses lattice micropatterning to improve the positioning of endothelial cells on EM grids, enabling more efficient cryo-electron tomography of cell-cell contacts.

Limited Dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

The paper shows that Dvl and Axin oligomerization dynamics regulate Wnt/β-catenin signaling efficiency by controlling β-catenin phosphorylation inhibition.

Extracellular matrix micropatterning technology for whole cell cryogenic electron microscopy studies

This paper introduces a technology to study mesoscale organization in epithelial cells under morphological modulation using ECM micropatterning for cryogenic electron microscopy.