ECM dimensionality tunes actin tension to modulate the endoplasmic reticulum and spheroid phenotype
F. Kai, G. Ou, R. W. Tourdot, C. Stashko, G. Gaietta, M. F. Swift, N. Volkmann, A. F. Long, Y. Han, H. H. Huang, J. J. Northey, A. M. Leidal, V. Viasnoff, D. M. Bryant, W. Guo, , V. M. Weaver
The paper shows that ECM dimensionality affects actin tension, which in turn modulates endoplasmic reticulum function and spheroid resilience in mammary epithelial cells.
bioRxiv · Jul 14, 2021 · PreprintCell Biology