Author

D. Quinkert

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Organism:rat· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

S. J. Draper· 6 shared A. M. Lias· 3 shared A. M. Minassian· 3 shared B. G. Williams· 3 shared C. A. Long· 3 shared I. Campeotto· 3 shared K. Miura· 3 shared S. E. Silk· 3 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersImmunology

S. J. Draper

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Author profile →

6 papers

Recent·Most cited

Analysis of the Diverse Antigenic Landscape of the Malaria Invasion Protein RH5 Identifies a Potent Vaccine-Induced Human Public Antibody Clonotype

J. R. Barrett, D. Pipini, N. D. Wright, A. J. R. Cooper, G. Gorini, D. Quinkert, A. M. Lias, H. Davies, C. Rigby, M. Aleshnick, B. G. Williams, W. J. Bradshaw, N. G. Paterson, T. Martinson, P. Kirtley, , S. J. Draper

The paper characterizes human antibodies against PfRH5, identifies key features of potent inhibitors, and demonstrates their prophylactic potential against malaria.

Cell · Sep 1, 2024Peer-reviewedImmunology

Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5

T. Harrison, N. Alam, B. Farrell, D. Quinkert, A. Lias, L. King, S. J. Draper, M. K. Higgins, I. Campeotto

This paper designs a malaria vaccine immunogen using structure-guided methods to present a single epitope from PfRH5, showing improved antibody response in rats compared to PfRH5 alone.

bioRxiv · Feb 29, 2024Immunology

Evaluation of Precision of the Plasmodium knowlesi Growth Inhibition Assay for Plasmodium vivax Duffy-Binding Protein-based Malaria Vaccine Development

J. E. Mertens, C. A. Rigby, M. Bardelli, D. Quinkert, M. M. Hou, A. Diouf, S. E. Silk, C. E. Chitnis, A. M. Minassian, R. W. Moon, C. A. Long, S. J. Draper, K. Miura

This study evaluates the precision of the Plasmodium knowlesi growth inhibition assay for Plasmodium vivax Duffy-binding protein-based malaria vaccine development, finding significant assay-to-assay variation in %GIA and GIA50.

bioRxiv · Jan 23, 2024Immunology

Preclinical Development of a Stabilized RH5 Virus-Like Particle Vaccine that Induces Improved Anti-Malarial Antibodies

L. D. W. King, D. Pulido, J. R. Barrett, H. Davies, D. Quinkert, A. M. Lias, S. E. Silk, D. J. Pattinson, A. Diouf, B. G. Williams, K. McHugh, A. Rodrigues, C. A. Rigby, V. Strazza, J. Suurbaar, , S. J. Draper

This paper develops a stabilized RH5 VLP vaccine that induces improved anti-malarial antibodies compared to a soluble protein vaccine in preclinical studies.

bioRxiv · Jan 4, 2024Immunology

The Dual Action of Human Antibodies Specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites

G. E. Weiss, R. J. Ragotte, D. Quinkert, A. M. Lias, M. G. Dans, C. Boulet, B. G. Williams, B. S. Crabb, S. J. Draper, P. R. Gilson

This paper shows that antibodies against PfRH5 and PfCyRPA block parasite invasion and inactivate extracellular merozoites by triggering a developmental pathway normally seen after invasion.

bioRxiv · Feb 7, 2023 · PreprintMicrobiology

Structure of the cysteine-rich domain of Plasmodium falciparum P113 identifies the location of the RH5 binding site

I. Campeotto, F. Galaway, S. Mehmood, L. Barfod, D. Quinkert, V. Kotraiah, T. W. Phares, K. E. Wright, A. P. Snijders, S. J. Draper, M. Higgins, G. J. Wright

The paper determines the structure of the RH5-binding region of P113 and identifies the binding site, providing insights for malaria vaccine development.

mBio · Oct 27, 2020Peer-reviewedMicrobiology