Author

E. J. Murphy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. P. Turnbull· 1 shared A. Pinto-Fernandez· 1 shared B. M. Kessler· 1 shared D. P. O'Brien· 1 shared E. C. Kennedy· 1 shared F. Guenther· 1 shared H. B. Jones· 1 shared J. B. Davis· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiochemistry

A. P. Turnbull

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Author profile →

2 papers

Recent·Most cited

Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2

W. J. Bradshaw, E. C. Kennedy, T. Moreira, L. A. Smith, R. Chalk, V. L. Katis, J. L. Benesch, P. E. Brennan, E. J. Murphy, O. Gileadi

The paper determines structures of SHIP1 and SHIP2 phosphatase and C2 domains, showing the C2 domain modulates phosphatase activity more in SHIP2 than SHIP1, providing insights for drug development.

bioRxiv · Jul 31, 2023Biochemistry

Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides

D. P. O'Brien, H. B. Jones, F. Guenther, E. J. Murphy, K. S. England, M. Anderson, P. Brennan, J. B. Davis, A. Pinto-Fernandez, A. P. Turnbull, B. M. Kessler

This study investigates how a benzosulfonamide compound inhibits USP30, a mitochondrial deubiquitylating enzyme, using biochemical and structural methods to reveal its binding mechanism and selectivity.

bioRxiv · Sep 13, 2022Biochemistry