W. J. Gan

A truncation mutant of adenomatous polyposis coli (APC) impairs apical cell extrusion through elevated epithelial tissue tension

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ channel function to control glucose dependent insulin secretion.

The paper shows local activation of focal adhesion kinase at the β cell capillary interface regulates presynaptic scaffold proteins and Ca2+ channel function to control glucose-dependent insulin secretion.