J. Tong

Stacking haplotypes from the Vavilov wheat collection to accelerate breeding for multiple disease resistance

This paper identifies haploblocks associated with multiple disease resistance in wheat using a diversity panel and demonstrates their potential to improve resistance through haplotype stacking.

The molecular basis of pine wilt disease resistance in Pinus massoniana

This study identifies three molecular resistance strategies in Pinus massoniana cultivars against pine wood nematodes using transcriptome and metabolome profiling.

Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

Intestinal Epithelial Heat Shock Protein 25/27 integrates host and microbial drivers of mucosal restitution following inflammatory injury

This study identifies Hsp25/27 as a key mediator of mucosal healing by integrating host and microbial signals in intestinal epithelial cells following inflammatory injury.

Parallel lipid-carried epitope pillars enhance stimulation of chimeric antigen receptor T cells

This study shows that glycosylphosphatidylinositol-anchored MUC1 epitope pillars enhance chimeric antigen receptor T cell stimulation, with tandem repeat sequences showing greater activity.

Local activation of focal adhesion kinase orchestrates the positioning of presynaptic scaffold proteins and Ca2+ channel function to control glucose dependent insulin secretion.

The paper shows local activation of focal adhesion kinase at the β cell capillary interface regulates presynaptic scaffold proteins and Ca2+ channel function to control glucose-dependent insulin secretion.

m6A modifications regulate intestinal immunity and rotavirus infection

This study shows that m6A modifications regulate intestinal immunity and rotavirus infection by modulating IRF7 and IFN expression through METTL3 in intestinal epithelial cells.

The cardiac STAT3 intercalated disc specific expression in tail suspension rat

This study examines right ventricle remodeling in tail-suspended rats under microgravity simulation, finding STAT3 accumulation and gap junction remodeling without significant hypertrophy.

Potent neutralization antibodies induced by a recombinant trimeric Spike protein vaccine candidate containing PIKA adjuvant for COVID-19

This study evaluates a recombinant trimeric Spike protein vaccine with PIKA adjuvant, showing high neutralizing antibody titers and efficacy against COVID-19.

The roles of wrinkle structures in the veins of Asian Ladybird and bioinspiration

This study examines how wrinkle structures in the veins of Asian ladybird hind wings affect deformation and flight performance, suggesting bioinspiration for micro air vehicle wing design.

An antibody drug conjugate targeting a GSTA glycosite-signature epitope of mucin1 expressed by non-small cell lung cancer

This paper develops an anti-MUC1 antibody-drug conjugate targeting a GSTA glycosite-signature epitope, showing potent antitumoral efficacy and low toxicity in NSCLC models.

Normal development and fertility of Fut1, Fut2, and Sec1 triple knockout mice

This study generates triple knockout mice lacking Fut1, Fut2, and Sec1 to deplete H antigen, finding normal development and fertility despite the absence of the antigen.

Illumina sequencing analysis of the ruminal microbiota in high-yield and low-yield lactating dairy cows

This study compares ruminal microbiota composition between high-yield and low-yield dairy cows using 16S rRNA gene sequencing, finding differences in bacterial abundance and community structure associated with milk production traits.