Author

J. Begun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. S. Yap· 2 shared E. C. Hardeman· 2 shared E. C. Hoedt· 2 shared M. A. McGuckin· 2 shared M. Morrison· 2 shared P. W. Gunning· 2 shared R. Giri· 2 shared A. Lepletier· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersCell Biology

A. S. Yap

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Author profile →

5 papers

Recent·Most cited

A truncation mutant of adenomatous polyposis coli (APC) impairs apical cell extrusion through elevated epithelial tissue tension

W. J. Gan, R. Giri, J. Begun, H. Abud, E. C. Hardeman, P. W. Gunning, A. S. Yap, I. Noordstra

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

bioRxiv · Mar 6, 2024Cell Biology

Pre-existing tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia

Z. Mann, F. Lim, S. Verma, B. N. Nanavati, J. M. Davies, J. Begun, E. C. Hardeman, P. W. Gunning, D. Subramanyam, A. S. Yap, K. Duszyc

This study shows that pre-existing mechanical tension at adherens junctions impairs apoptotic extrusion in epithelia, and this effect can be reversed by reducing tension.

bioRxiv · Aug 31, 2023Cell Biology

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

H. Weerakoon, J. Straube, K. Lineburg, L. Cooper, S. Lane, C. Smith, S. Alabbas, J. Begun, J. J. Miles, M. M. Hill, A. Lepletier

The paper identifies CD49f-expressing subsets of human regulatory T cells with distinct transcriptional profiles and functions linked to ulcerative colitis disease activity.

bioRxiv · Feb 22, 2021Immunology

Secreted microbial metabolites modulate gut immunity and inflammatory tone

R. Giri, E. C. Hoedt, K. Shamsunnahar, M. A. McGuckin, M. Morrison, R. J. Capon, J. Begun, P. O. Cuiv

The paper identifies gut bacteria that suppress NF-κB activity and inflammatory responses, suggesting microbiome modulation as a potential therapeutic strategy for IBD.

bioRxiv · Dec 16, 2019 · PreprintMicrobiology

Enterococcus faecalis AHG0090 is a genetically tractable bacterium and produces a secreted peptidic bioactive that suppresses NF-kB activation in human gut epithelial cells

P. O Cuiv, R. Giria, E. C. Hoedt, M. A. McGuckin, J. Begun, M. Morrison

The paper isolates and characterizes E. faecalis AHG0090, showing it suppresses NF-κB activation in human gut cells and produces a heat- and protease-resistant peptidic bioactive.

bioRxiv · Mar 3, 2018Microbiology