A. K. Coleman

HnRNPA2B1 tunes antimycobacterial immune responses in macrophages through alternative splicing of Irgm1

This study identifies hnRNPA2B1 as a splicing regulator that modulates anti-mycobacterial immune responses in macrophages by controlling alternative splicing of Irgm1.

Na+/K+ATPase - Cav1.2 nanodomain differentially regulates intracellular and local adrenergic signaling in cardiac myocytes

The paper investigates how the NKA1-Cav1.2 nanodomain differentially regulates intracellular Na+ and Ca2+ homeostasis in atrial and ventricular myocytes through local adrenergic signaling.

Serine arginine-rich splicing factor (SRSF7) cooperates with the histone methyltransferase KMT5a to promote the type I interferon response via transcriptional activation of IRF7

This study identifies SRSF7's role in promoting the type I interferon response by transcriptionally activating IRF7 through cooperation with KMT5a.

Calcium and Bicarbonate Signaling Pathways have Pivotal, Resonating Roles in Matching ATP Production to Demand

This study identifies bicarbonate signaling via sAC as a third regulatory system that complements Ca2+ signaling to control mitochondrial ATP production in cardiac myocytes.

Mitochondrial dysfunction promotes alternative gasdermin D-mediated inflammatory cell death and susceptibility to infection

This study shows that mitochondrial dysfunction caused by Lrrk2G2019S promotes non-pyroptotic cell death via GSDMD and increases susceptibility to infection.

Heterologous flavivirus exposure provides varying degrees of cross-protection from Zika virus in a mouse model of infection

This study shows that prior exposure to different flaviviruses provides varying levels of protection against Zika virus in mice, with primary Zika infection being most protective.

Tubulin acetylation increases cytoskeletal stiffness to regulate mechanotransduction in striated muscle

The paper investigates how acetylated α-tubulin affects cytoskeletal stiffness and mechanotransduction in striated muscle by increasing its levels without changing detyrosinated α-tubulin.