Author

W. J. Leonard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

J.-X. Lin· 2 shared B. Shin· 1 shared C. Liu· 1 shared E. C. K. Wan· 1 shared E. E. West· 1 shared E. K. Leonard· 1 shared E. R. Johansen· 1 shared E. V. Rothenberg· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

J.-X. Lin

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Author profile →

2 papers

Recent·Most cited

Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity

E. K. Leonard, J. Tomala, J. R. Gould, M. I. Leff, J.-X. Lin, P. Lin, M. J. Porter, E. R. Johansen, L. Thompson, S. D. Cao, T. Henclova, M. Huliciak, O. Vanek, M. Kovar, W. J. Leonard, J. B. Spangler

This paper develops an IL-2/antibody fusion protein that enhances immune effector cell activation and antitumor activity while reducing toxicity compared to natural IL-2.

bioRxiv · May 3, 2023Bioengineering

Distinct super-enhancer elements differentially control Il2ra gene expression in a cell-type specific fashion

R. Spolski, P. Li, V. Chandra, B. Shin, C. Liu, J. Oh, M. Ren, Y. Enomoto, E. E. West, S. Christensen, E. C. K. Wan, M. Ge, J.-X. Lin, P. Vijayanand, E. V. Rothenberg, W. J. Leonard

The paper identifies distinct super-enhancer elements that differentially regulate Il2ra expression in DN2/DN3 thymocytes and Treg cells versus mature T and NK cells.

bioRxiv · Nov 18, 2022 · PreprintImmunology