Author

T. Henclova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

J. B. Spangler· 2 shared J. Tomala· 2 shared A. G. Dykema· 1 shared A. R. Cross· 1 shared A. S. Meyer· 1 shared A. Young· 1 shared B. T. Orcutt-Jahns· 1 shared C. A. Hunter· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBioengineering

J. B. Spangler

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2 papers

Recent·Most cited

Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity

E. K. Leonard, J. Tomala, J. R. Gould, M. I. Leff, J.-X. Lin, P. Lin, M. J. Porter, E. R. Johansen, L. Thompson, S. D. Cao, T. Henclova, M. Huliciak, O. Vanek, M. Kovar, W. J. Leonard, J. B. Spangler

This paper develops an IL-2/antibody fusion protein that enhances immune effector cell activation and antitumor activity while reducing toxicity compared to natural IL-2.

bioRxiv · May 3, 2023Bioengineering

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

D. VanDyke, M. Iglesias, J. Tomala, A. Young, J. Smith, J. A. Perry, E. Gebara, A. R. Cross, L. S. Cheung, A. G. Dykema, B. T. Orcutt-Jahns, T. Henclova, J. Golias, J. Balolong, L. M. Tomasovic, , J. B. Spangler

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

bioRxiv · May 29, 2022Bioengineering