J. B. Spangler

Synergistic activity of IL-2 mutein with tolerogenic ImmTOR nanoparticles leads to massive expansion of antigen-specific Tregs and protection against autoimmune disease

This study shows that combining IL-2 mutein with ImmTOR nanoparticles expands antigen-specific Tregs and protects against autoimmune diseases.

Engineered cytokine/antibody fusion proteins improve delivery of IL-2 to pro-inflammatory cells and promote antitumor activity

This paper develops an IL-2/antibody fusion protein that enhances immune effector cell activation and antitumor activity while reducing toxicity compared to natural IL-2.

Lung tumor-infiltrating Treg have divergent transcriptional profiles and function linked to checkpoint blockade response

The paper identifies 10 subsets of lung cancer-infiltrating Tregs, showing one subset is suppressive and linked to anti-PD-1 resistance while another is Th1-like and associated with PD-1 response.

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

Massively parallel encapsulation of single cells with structured microparticles and secretion-based flow sorting

This paper introduces a method to sort single cells based on secreted products using microparticles, enabling high-throughput screening of cell function.