Super-resolution imaging reveals the evolution of higher-order chromatin folding in early carcinogenesis
J. Xu, H. Ma, H. Ma, W. Jiang, M. Duan, S. Zhao, C. Gao, E.-R. Hahm, S. Lardo, K. Troy, M. Sun, R. Pai, D. Stolz, S. Singh, R. Brand, , Y. Liu
The paper uses super-resolution imaging to show that chromatin structure decompacts and fragments during early cancer development, even before tumors form, and this change may improve cancer detection and risk assessment.
bioRxiv · Jun 17, 2019Cancer Biology