W. Jiang

Binding Free Energies of Piezo1 Channel Agonists at Protein-Membrane Interface

This study computes binding free energies of Yoda1 and its analogs at Piezo1 channels using molecular dynamics to predict agonist/inhibitor effects and guide drug design.

Protective human anti-poxvirus monoclonal antibodies are generated from rare memory B cells isolated by multicolor antigen tetramers

The paper isolates rare memory B cells from vaccinated individuals to generate anti-poxvirus monoclonal antibodies, identifying one with high efficacy against viral infection.

-Labeled PARP-1 PET Imaging of PSMA Targeted Alpha Particle Radiotherapy Response

This study uses [18F]-PARPZ PET imaging to assess alpha particle radiotherapy response in prostate cancer xenografts by tracking PARP-1 expression changes.

Impact of various vaccine boosters on neutralization against Omicron following prime vaccinations with inactivated or adenovirus-vectored vaccine

This study evaluates the effectiveness of various vaccine boosters against the Omicron variant following prime vaccinations with inactivated or adenovirus-vectored vaccines, finding that certain boosters significantly enhance neutralizing activity.

Scale Bar of Aging Trajectories for Screening Personal Rejuvenation Treatments

This study develops an aging clock based on blood transcriptome data to assess aging rates and evaluate rejuvenation treatments like NMN and Metformin.

Importance of Molecular Dynamics Equilibrium Protocol on Protein-lipid Interactions near Channel Pore

The paper identifies an artifact in hybrid MD simulations of ion channel pores caused by differences in solvation and equilibrium protocols between coarse-grained and all-atom models, and proposes a solution to correct it.

Identification and Characterization of Stem Cells in Mammalian Esophageal Stratified Squamous Epithelia

This study identifies and characterizes quiescent stem cells in the mammalian esophageal epithelium using scRNA-seq and DNA methylation profiling in rat models.

Bone marrow mesenchymal stem cells stimulated by tumor necrosis factor-α can promote the repair of fatty liver cell oxidative stress injury and fatty liver ischemia-reperfusion injury

This study shows that TNF-α-stimulated BMSCs reduce oxidative stress and tissue damage in fatty liver IRI in rats.

Immunoglobulin-producing AT2-like cells secrete IgA into the extracellular matrix in pulmonary fibrosis

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

Emergence of an adaptive epigenetic cell state in human bladder urothelial carcinoma evolution

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

Tuning DO:DM ratios modulates MHC class II immunopeptidomes

This study investigates how varying DO:DM ratios affect MHC-II immunopeptidomes by analyzing HLA-DR4-expressing cell lines with different ratios, revealing peptide characteristics influencing presentation.

A highly conserved lipase deacylates oxidized phospholipids and ameliorates acute lung injury

This study identifies AOAH as a lipase that deacylates oxidized phospholipids, reducing inflammation and acute lung injury in vivo.

Metabolomics and microbiome reveal impacts of rhizosphere metabolites on alfalfa continuous cropping

This study identifies rhizosphere metabolites and microbial shifts in alfalfa soils under continuous cropping, showing autotoxic substances like p-coumaric acid contribute to crop obstacles.

ICER controls HIV-1 infection and replication in elite controllers

The paper identifies ICER as a host factor that contributes to HIV resistance in elite controllers by regulating HIV-1 replication through alternative splicing and promoter activity.

Classical swine fever virus NS5A inhibits NF-κB signaling by targeting NEMO

This paper identifies that NS5A of CSFV inhibits NF-κB signaling by degrading NEMO and blocking its k63-linked polyubiquitination.

Structure-based design of a highly stable, covalently-linked SARS-CoV-2 spike trimer with improved structural properties and immunogenicity

This paper designs a modified SARS-CoV-2 spike trimer, VFLIP, with enhanced stability, immunogenicity, and structural fidelity to the native spike.

An inter-channel cooperative mechanism mediates PIEZO1's exquisite mechanosensitivity

This study shows that PIEZO1 channels exhibit cooperative behavior under mechanical stress, enhancing their sensitivity to small tension changes through inter-channel interactions.

A Piezo1 open state reveals a multi-fenestrated ion permeation pathway

The paper uses molecular dynamics simulations to study Piezo1 channel opening and identifies a multi-fenestrated ion permeation pathway.

Free energy and kinetics of cAMP permeation through connexin26 hemichannel with and without voltage

This study investigates the free energy and kinetics of cAMP permeation through connexin26 hemichannels using simulations, revealing binding sites, directional transition rates, and the role of voltage and ions.

The bone microenvironment invigorates metastatic seeds for further dissemination

This study shows the bone microenvironment enhances metastatic potential of cancer cells, enabling further dissemination and multi-organ metastasis, independent of genetic selection.

Genetic determinants of COVID-19 drug efficacy revealed by genome-wide CRISPR screens

This study identifies genetic determinants of COVID-19 drug efficacy using genome-wide CRISPR screens, revealing genes involved in drug metabolism and immunosuppressive effects.

Target lipidomics reveals associations between serum sphingolipids and insulin sensitivity by the glucose clamp

This study identifies serum sphingolipids associated with insulin sensitivity using lipidomics and glucose clamp techniques, finding SM/Cer and SM d18:0/26:0 as potential biomarkers.

Structural and functional analysis of female sex hormones against SARS-Cov2 cell entry

This study investigates how female sex hormones, specifically estrogens, may protect against SARS-CoV-2 infection by disrupting glycan interactions involved in viral entry.

A novel biparatopic antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy

The paper develops a biparatopic antibody-ACE2 fusion (89C8-ACE2) that effectively blocks SARS-CoV-2 infection in vitro and neutralizes authentic virus at low nanomolar concentrations.

Inducible Depletion of Calpain-2 Mitigates Abdominal Aortic Aneurysm in Mice

This study shows that calpain-2 depletion reduces abdominal aortic aneurysm (AAA) progression and rupture in mice by preserving cytoskeletal proteins and ECM integrity.

Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in industrial Streptomyces

This paper develops an endogenous quorum-sensing based CRISPRi circuit (EQCi) to dynamically regulate multiple targets in Streptomyces, achieving higher rapamycin titers without affecting cell growth.

High-fidelity continuum modeling predicts avian voiced sound production

The paper develops and validates a high-fidelity 3D continuum model for avian voiced sound production, showing it accurately predicts vibratory and acoustic traits.

Individualized ctDNA Fingerprints to Monitor Treatment Response and Recurrence in Multiple Cancer Types

The paper develops individualized ctDNA fingerprint panels to monitor treatment response and recurrence across multiple cancer types using whole-exome sequencing data.

A visualizable hepatitis A virus and hepatitis C virus coinfection model in vitro: coexistence of two hepatic viruses under limited competition in viral RNA synthesis

This study establishes an in vitro model of HAV/HCV coinfection and finds mild reciprocal viral interference due to competition for rNTPs in RNA synthesis, suggesting indirect interactions explain HCV suppression in coinfected patients.

CD155/CD96 promotes immunosuppression in lung adenocarcinoma (LUAD)

This study shows CD155/CD96 promotes immunosuppression in LUAD by inhibiting antitumor immune responses and up-regulating CD96 in CD8 T cells, with potential therapeutic implications.