Author

W. L. Tam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

A. Aiderus· 1 shared A. C. Tan· 1 shared A. D. Jeyasekharan· 1 shared A. J. Sanderup· 1 shared A. Jain· 1 shared A. Shendre· 1 shared A. Takano· 1 shared A. W.-C. Koh· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

A. Aiderus

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Multi-region spatial transcriptome analysis reveals cellular networks and pathways associated with hepatocellular carcinoma recurrence

A. Aiderus, P. V. Seshachalam, K. Idzham, M. Caldez, R. Shanmugam, I. N. Sari, D. H. H. Ying, S. L. Chong, K. Sekar, S. C. Chew, G. B. Chen, A. Y.-F. Chung, P. C. Cheow, J. H. Kam, A. W.-C. Koh, , P. K. H. Chow

This study uses spatial transcriptomics to analyze HCC tumor sectors and identifies endothelial cell enrichment and ligand-receptor interactions linked to disease recurrence.

bioRxiv · Jul 26, 2023 · PreprintCancer Biology

Dearth of smoking-induced mutations in NSRO-driven non-small-cell lung cancer despite smoking exposure

C.-Y. Huang, N. Jiang, M. Shen, G. Lai, A. C. Tan, A. Jain, S. P. Saw, M.-K. Ang, Q. S. Ng, D. W.-T. Lim, R. Kanesvaran, E.-H. Tan, W. L. Tan, B.-H. Ong, K. L. Chua, , S. G. Rozen

The paper examines genomic and transcriptomic changes in NSRO-driven NSCLCs in smokers and non-smokers, finding no smoking-induced mutations but higher transcriptomic cell cycle activity in smokers.

bioRxiv · Jul 4, 2023 · PreprintCancer Biology

PLK1 inhibition selectively kills ARID1A deficient cells through uncoupling of oxygen consumption from ATP production

U. S. Srinivas, G. K. Ramachandran, J. D. Wardyn, M. M. Hoppe, Y. Peng, S. Lim, M. Y. Lee, P. C. Peethala, O. An, A. Shendre, B. W. Q. Tan, T. S. C. Norbert, P. Jaynes, L. Hu, R. Jakhar, , A. D. Jeyasekharan

This study identifies ARID1A deficiency as a biomarker for PLK1 inhibitor sensitivity by revealing a mitochondrial metabolic vulnerability in these cells.

bioRxiv · Jun 1, 2021 · PreprintCancer Biology