Author

S. G. Rozen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Assay:whole-genome sequencing· 3 Research Focus:variant calling· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Boot· 2 shared A. W. T. Ng· 2 shared M. N. Huang· 2 shared A. C. Tan· 1 shared A. Dhawan· 1 shared A. J. Sanderup· 1 shared A. Jain· 1 shared A. Takano· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersCancer Biology

A. Boot

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Author profile →

4 papers

Recent·Most cited

Dearth of smoking-induced mutations in NSRO-driven non-small-cell lung cancer despite smoking exposure

C.-Y. Huang, N. Jiang, M. Shen, G. Lai, A. C. Tan, A. Jain, S. P. Saw, M.-K. Ang, Q. S. Ng, D. W.-T. Lim, R. Kanesvaran, E.-H. Tan, W. L. Tan, B.-H. Ong, K. L. Chua, , S. G. Rozen

The paper examines genomic and transcriptomic changes in NSRO-driven NSCLCs in smokers and non-smokers, finding no smoking-induced mutations but higher transcriptomic cell cycle activity in smokers.

bioRxiv · Jul 4, 2023 · PreprintCancer Biology

Acetyl-CoA metabolism drives epigenome change and contributes to carcinogenesis risk in fatty liver disease

G. Assante, S. Chandrasekaran, S. Ng, A. Tourna, C. H. Chung, K. A. Isse, C. Filippi, A. Dhawan, M. Liu, S. G. Rozen, M. Hoare, P. Campbell, J. W. O. Ballard, N. Turner, M. J. Morris, , N. A. Youngson

This study shows that acetyl-CoA metabolism in fatty liver disease leads to histone hyperacetylation, DNA damage, and increased mutation risk, contributing to hepatocellular carcinoma.

bioRxiv · Jul 22, 2021Cancer Biology

The Repertoire of Mutational Signatures in Human Cancer

L. Alexandrov, J. Kim, N. J. Haradhvala, M. N. Huang, A. W. T. Ng, Y. Wu, A. Boot, K. R. Covington, D. A. Gordenin, E. Bergstrom, S. M. A. Islam, N. Lopez-Bigas, L. J. Klimczak, J. R. McPherson, S. Morganella, , M. R. Stratton

The paper characterizes 49 mutational signatures in human cancer using a large dataset of somatic mutations, revealing associations with exposures and DNA repair mechanisms and identifying signatures of unknown origin.

bioRxiv · Jul 3, 2019Cancer Biology

In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors

A. Boot, M. N. Huang, A. W. T. Ng, S.-C. Ho, J. Q. Lim, Y. Kawakami, K. Chayama, B. T. Teh, H. Nakagawa, S. G. Rozen

This study identifies the mutational signature of cisplatin in human cell lines and tumors, enabling detection of cisplatin exposure in hepatocellular and esophageal cancers.

bioRxiv · Dec 17, 2017Cancer Biology