Author

W. O. Ouyang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 3 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 2 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:structural biology· 1 Organism:virus· 1

Frequent Co-Authors

N. C. Wu· 4 shared T. J. C. Tan· 4 shared I. A. Wilson· 3 shared M. Yuan· 3 shared R. Lei· 3 shared C. Kieffer· 2 shared G. Song· 2 shared K. A. Matreyek· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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4 shared papersBiochemistry

N. C. Wu

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Functional and antigenic characterization of SARS-CoV-2 spike fusion peptide by deep mutational scanning

R. Lei, E. Qing, A. Odle, M. Yuan, T. J. C. Tan, N. So, W. O. Ouyang, I. A. Wilson, T. Gallagher, S. Perlman, N. C. Wu, L. Y. R. Wong

This study uses deep mutational scanning to analyze the SARS-CoV-2 spike fusion peptide, identifying mutations affecting viral entry and antibody resistance.

bioRxiv · Nov 28, 2023Microbiology

Widespread impact of immunoglobulin V gene allelic polymorphisms on antibody reactivity

M. Yuan, Z. Feng, H. Lv, N. So, I. R. Shen, T. J. C. Tan, Q. W. Teo, W. O. Ouyang, L. Talmage, I. A. Wilson, N. C. Wu

This study shows that IGV allelic polymorphisms widely affect antibody reactivity by analyzing antibody-antigen structures and experimental data.

bioRxiv · Jun 6, 2023Immunology

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

T. J. C. Tan, Z. Mou, R. Lei, W. O. Ouyang, M. Yuan, G. Song, R. Andrabi, I. A. Wilson, C. Kieffer, X. Dai, K. A. Matreyek, N. C. Wu

The paper identifies mutations that stabilize the prefusion conformation of SARS-CoV-2 spike while improving expression, using a combination of fluorescence-based assays, cell display, and deep mutational scanning.

bioRxiv · Sep 24, 2022Biochemistry

Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning

W. O. Ouyang, T. J. C. Tan, R. Lei, G. Song, C. Kieffer, R. Andrabi, K. A. Matreyek, N. C. Wu

This study quantifies the effects of NTD mutations on S protein expression and identifies mutations that enhance expression without altering antigenicity.

bioRxiv · Jun 20, 2022Biochemistry