Author

C. Kieffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Microbiology· 2 Bioengineering· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

G. Song· 2 shared K. A. Matreyek· 2 shared N. C. Wu· 2 shared R. Andrabi· 2 shared R. Lei· 2 shared T. J. C. Tan· 2 shared T. Zhang· 2 shared W. O. Ouyang· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersBiochemistry

G. Song

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6 papers

Recent·Most cited

Monocyte to macrophage differentiation and changes in cellular redox homeostasis promote cell type-specific HIV latency reactivation

A. Blanco, R. A. Coronado, N. Arun, K. Ma, R. D. Dar, C. Kieffer

This study shows that monocyte-to-macrophage differentiation and redox changes influence HIV latency differently in cell types, with macrophages being more responsive to redox modulators.

bioRxiv · Feb 12, 2024Microbiology

High-throughput identification of prefusion-stabilizing mutations in SARS-CoV-2 spike

T. J. C. Tan, Z. Mou, R. Lei, W. O. Ouyang, M. Yuan, G. Song, R. Andrabi, I. A. Wilson, C. Kieffer, X. Dai, K. A. Matreyek, N. C. Wu

The paper identifies mutations that stabilize the prefusion conformation of SARS-CoV-2 spike while improving expression, using a combination of fluorescence-based assays, cell display, and deep mutational scanning.

bioRxiv · Sep 24, 2022Biochemistry

Probing the biophysical constraints of SARS-CoV-2 spike N-terminal domain using deep mutational scanning

W. O. Ouyang, T. J. C. Tan, R. Lei, G. Song, C. Kieffer, R. Andrabi, K. A. Matreyek, N. C. Wu

This study quantifies the effects of NTD mutations on S protein expression and identifies mutations that enhance expression without altering antigenicity.

bioRxiv · Jun 20, 2022Biochemistry

In vitro characterization of engineered red blood cells as potent viral traps against HIV-1 and SARS-CoV-2

M. A. G. Hoffmann, C. Kieffer, P. J. Bjorkman

This study engineers red blood cells to express viral receptors, demonstrating their ability to neutralize HIV-1 and SARS-CoV-2 in vitro.

bioRxiv · Dec 20, 2020Bioengineering

Deletion of intestinal SHP impairs short-term response to cholic acid challenge in mice.

J. T. Nguyen, R. Riessen, T. Zhang, C. Kieffer, S. Anakk

This study shows that deleting SHP in the intestine of mice impairs their response to cholic acid, affecting bile acid levels and transporters without altering FXR mRNA.

bioRxiv · Sep 2, 2020Physiology

Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice

J. D. Ventura, J. Beloor, E. J. Allen, T. Zhang, K. Haugh, P. Uchil, C. Ochsenbauer, C. Kieffer, P. Kumar, T. J. Hope, W. Mothes

This study uses bioluminescent imaging to monitor HIV-1 infection dynamics in humanized mice during and after antiretroviral therapy, showing rebound in previously infected lymphoid tissues.

bioRxiv · Aug 24, 2019Microbiology