Author

W. R. Jacobs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

J. Kim· 2 shared S. Rajagopalan· 2 shared S. Tiwari· 2 shared A. Burgess· 1 shared A. G. Coyne· 1 shared B. C. Herold· 1 shared B. Chen· 1 shared C. Abell· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersMicrobiology

J. Kim

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Boosting bactericidal immunity of a recombinant Mycobacterium smegmatis strain via zinc-dependent ribosomal proteins

S. Singh, D. Kanzin, S. Chavez, N. A. Saavedra-Avila, T. Ng, R. Lukos, O. Mayer, J. Kim, B. Chen, M. Chen, S. Porcelli, W. R. Jacobs, S. Tiwari

This study shows that IKEPLUS, a recombinant Mycobacterium smegmatis strain, provides better protection against Mtb infection than BCG in mice when grown in low zinc media.

bioRxiv · Dec 11, 2023 · PreprintMicrobiology

The PDIM paradox of Mycobacterium tuberculosis: new solutions to a persistent problem

C. V. Mulholland, T. J. Wiggins, J. Cui, C. Vilcheze, S. Rajagopalan, M. W. Shultis, E. Z. Reyes-Fernandez, W. R. Jacobs, M. Berney

The paper identifies a metabolic deficiency causing PDIM loss in Mycobacterium tuberculosis and shows how nutrient supplementation can restore PDIM production and virulence.

bioRxiv · Oct 16, 2023Microbiology

The SapM phosphatase arrests phagosome maturation in an ESX-1 independent manner in Mycobacterium tuberculosis and BCG

C. Xander, S. Rajagopalan, W. R. Jacobs, M. Braunstein

This study shows SapM phosphatase induces phagosome maturation arrest in Mycobacterium tuberculosis and BCG without requiring the ESX-1 secretion system.

bioRxiv · Feb 13, 2023Microbiology

A Fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis.

P. Gupta, S. E. Thomas, J. Cory-Wright, V. Sebastián-Pérez, A. Burgess, E. Cattermole, C. Meghir, C. Abell, A. G. Coyne, W. R. Jacobs, T. L. Blundell, S. Tiwari, V. Mendes

This study uses a fragment-based approach to assess the ligandability of four enzymes in the L-arginine biosynthesis pathway of M. tuberculosis, identifying potential drug targets.

bioRxiv · Mar 12, 2021Biochemistry

Increased disease burden in Interleukin-3 deficient mice after Mycobacterium tuberculosis and herpes simplex virus infections

S. Kunnath-Velayudhan, T. W. Ng, N. K. Saini, M. F. Goldberg, P. Arora, J. Xu, J. Kim, B. C. Herold, J. Chan, W. R. Jacobs, S. A. Porcelli

This study shows that IL-3 deficiency increases disease severity in mice infected with M. tuberculosis and HSV-1/HSV-2.

bioRxiv · Mar 7, 2021 · PreprintImmunology