Author

W. R. McCombie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Plant Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. Kramer· 4 shared E. Hodges· 2 shared K. Chang· 2 shared O. Klingbeil· 2 shared S. Goodwin· 2 shared Y. Wei· 2 shared Z. Yang· 2 shared A. Rishi· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersCancer Biology

M. Kramer

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Author profile →

4 papers

Recent·Most cited

MaizeCODE reveals bi-directionally expressed enhancers that harbor molecular signatures of maize domestication.

J. Cahn, M. Regulski, J. Lynn, E. Ernst, C. de Santis Alves, S. Ramakrishnan, K. Chougule, S. Wei, Z. Lu, X. Xu, J. Drenkow, M. Kramer, A. Seetharam, M. B. Hufford, W. R. McCombie, , R. A. Martienssen

The paper identifies bi-directionally expressed enhancers in maize with domestication signatures using integrated epigenomic and transcriptomic data from multiple tissues and inbred lines.

bioRxiv · Feb 22, 2024Plant Biology

Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics

S. Bhatia, M. Kramer, S. Russo, P. Naik, G. Arun, K. Brophy, P. A. Andrews, C. Fan, C. M. Perou, J. Preall, T. Ha, D. Plenker, D. Tuveson, A. Rishi, J. E. Wilkinson, , D. L. Spector

This study develops and characterizes patient-derived TNBC organoids that recapitulate tumor properties and identify key signaling pathways involved in cancer progression.

bioRxiv · Aug 9, 2021Cancer Biology

In vivo genetic screen identifies a SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia

Y. Wei, S. Iyer, S. Costa, Z. Yang, M. Kramer, E. Adelman, O. Klingbeil, O. Demerdash, S. Polyanskaya, K. Chang, S. Goodwin, E. Hodges, W. R. McCombie, M. Figueroa, C. Vakoc

The paper identifies SLC5A3-dependent myo-inositol auxotrophy in AML through genetic screening and shows synthetic lethality between ISYNA1 and SLC5A3.

bioRxiv · Dec 22, 2020 · PreprintCancer Biology

Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins

Z. Yang, Y. Wei, X. S. Wu, S. V. Iyer, M. Jung, E. R. Adelman, O. Klingbeil, M. Kramer, O. E. Demerdash, K. Chang, S. Goodwin, E. Hodges, W. R. McCombie, M. E. Figueroa, A. Smogorzewska, C. R. Vakoc

This study identifies ALDH2 transcriptional silencing in AML as a dependency on FA proteins, suggesting FA pathway targeting as a therapeutic strategy.

bioRxiv · Oct 23, 2020Cancer Biology