Author

X. S. Wu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Approach:genetic perturbation / CRISPR· 2 Approach:benchmark study· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. R. Vakoc· 4 shared O. E. Demerdash· 2 shared O. Klingbeil· 2 shared T. D. D. Somerville· 2 shared A. M. Chinnaiyan· 1 shared A. Parolia· 1 shared A. Smogorzewska· 1 shared A. W. Ying· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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4 shared papersCancer Biology

C. R. Vakoc

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4 papers

Recent·Most cited

Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies

T. He, L. Xiao, Y. Qiao, O. Klingbeil, E. Young, X. S. Wu, R. Mannan, S. Mahapatra, S. Eyunni, J. C.-Y. Tien, X. Wang, Y. Zheng, N. Kim, H. Zheng, S. Hou, , A. M. Chinnaiyan

This study identifies a therapeutic vulnerability in POU2F-POU2AF-driven cancers by showing that targeting the mSWI/SNF complex with a PROTAC degrader reduces tumor growth in preclinical models.

bioRxiv · Jan 22, 2024Cancer Biology

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

L. Duplaquet, K. So, A. W. Ying, X. Li, Y. Li, X. Qiu, R. Li, S. Singh, X. S. Wu, Q. Liu, J. Qi, T. D. D. Somerville, H. Heiling, E. Mazzola, Y. Lee, , M. G. Oser

This study identifies mSWI/SNF complex activity as a targetable dependency in POU2F3-positive small cell lung cancer, showing that inhibiting mSWI/SNF or BRD9 reduces tumor growth and improves survival.

bioRxiv · Jan 21, 2024Cancer Biology

p73 activates transcriptional signatures of basal lineage identity and ciliogenesis in pancreatic ductal adenocarcinoma

S. K. Hur, T. D. D. Somerville, X. S. Wu, D. Maia-Silva, O. E. Demerdash, D. A. Tuveson, F. Notta, C. R. Vakoc

This study shows p73 activates basal lineage and ciliogenesis genes in PDAC, suggesting its role in lineage plasticity and tumor progression.

bioRxiv · Apr 20, 2023 · PreprintCancer Biology

Transcriptional silencing of ALDH2 in acute myeloid leukemia confers a dependency on Fanconi anemia proteins

Z. Yang, Y. Wei, X. S. Wu, S. V. Iyer, M. Jung, E. R. Adelman, O. Klingbeil, M. Kramer, O. E. Demerdash, K. Chang, S. Goodwin, E. Hodges, W. R. McCombie, M. E. Figueroa, A. Smogorzewska, C. R. Vakoc

This study identifies ALDH2 transcriptional silencing in AML as a dependency on FA proteins, suggesting FA pathway targeting as a therapeutic strategy.

bioRxiv · Oct 23, 2020Cancer Biology