The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state and its deletion improves checkpoint blockade
S. E. McClory, O. Bardhan, K. S. Rome, J. R. Giles, A. E. Baxter, L. Xu, P. A. Gimotty, R. B. Faryabi, E. J. Wherry, W. S. Pear, M. S. Jordan
This study shows that deleting Trib1 shifts exhausted T cells to a KLR+ CD8+ effector state, enhancing viral clearance and checkpoint inhibitor response.
bioRxiv · Feb 16, 2023Immunology