Author

G. Vahedi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Approach:experimental assay· 4 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

A. Naji· 3 shared K. H. Kaestner· 3 shared M. Fasolino· 3 shared A. Chandra· 2 shared C. Liu· 2 shared E. J. Wherry· 2 shared M. Brissova· 2 shared N. Goldman· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

A. Naji

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Aberrant TNF signaling in pancreatic lymph nodes of patients with Type 1 Diabetes

M. Abedi, P. Rai, Y. Zhou, C. Liu, I. Johnson, A. Chandra, M. Fasolino, S. Rostami, K. H. Kaestner, A. Naji, R. B. Faryabi, G. Vahedi

This study identifies heightened TNF pathway activity and chromatin remodeling in pancreatic lymph node CD4+ T cells from T1D patients, supporting the use of TNF inhibitors in clinical trials.

bioRxiv · May 31, 2024 · PreprintImmunology

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

A. J. Dimitri, A. E. Baxter, G. M. Chen, C. R. Hopkins, G. T. Rouin, H. Huang, W. Kong, C. H. Holliday, V. Wiebking, R. Bartoszek, S. Drury, K. Dalton, O. M. Koucky, Z. Chen, J. R. Giles, , J. A. Fraietta

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

bioRxiv · Mar 29, 2024Immunology

Alpha cell dysfunction in early type 1 diabetes

N. Doliba, A. Rozo, J. Roman, W. Qin, D. Traum, L. Gao, J. Liu, E. Manduchi, C. Liu, M. Golson, G. Vahedi, A. Naji, F. Matschinsky, M. Atkinson, A. Powers, , D. Stoffers

The paper identifies early alpha cell dysfunction in individuals with GADA+ status, preceding beta cell loss in T1D, and links it to metabolic pathway abnormalities.

bioRxiv · Oct 15, 2021 · PreprintPhysiology

SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells

K. C. Coate, J. Cha, S. Shrestha, W. Wang, L. M. Goncalves, J. Almaca, M. E. Kapp, M. Fasolino, A. Morgan, C. Dai, D. C. Saunders, R. Bottino, R. Aramandla, R. Jenkins, R. Stein, , A. C. Powers

The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.

bioRxiv · Aug 31, 2020 · PreprintCell Biology

The identity of human tissue-emigrant CD8+ T cells

M. Buggert, L. A. Vella, S. Nguyen, V. Wu, T. Sekine, A. Perez-Potti, C. R. Maldini, S. Manne, S. Darko, A. Ransier, L. Kuri-Cervantes, A. Sada Japp, I. Bukh Brody, M. A. Ivarsson, L. Hertwig, , M. R. Betts

The paper characterizes tissue-emigrant CD8+ T cells in humans and non-human primates, revealing distinct migratory behaviors and clonal dynamics.

bioRxiv · Aug 11, 2020Immunology

Oncogenic Notch promotes long-range regulatory interactions within hyperconnected 3D cliques

J. Petrovic, Y. Zhou, M. Fasolino, N. Goldman, G. Schwartz, M. Mumbach, S. Nguyen, K. Rome, Y. Sela, Z. Zapataro, S. Blacklow, M. Kruhlak, J. Aster, J. Shi, E. Joyce, , R. B. Faryabi

bioRxiv · Jan 22, 2019Cancer Biology