N. Goldman

TET2 regulates early and late transitions in exhausted CD8+ T-cell differentiation and limits CAR T-cell function

This study shows that targeting TET2 in CAR T-cells improves their anti-tumor responses by limiting terminal exhaustion and enhancing therapeutic potential.

The SARS-CoV-2 replication-transcription complex is a priority target for broad-spectrum pan-coronavirus drugs

The paper identifies two highly conserved druggable sites in the SARS-CoV-2 replication-transcription complex as potential targets for broad-spectrum antiviral drugs.

Mutation rates and selection on synonymous mutations in SARS-CoV-2

The paper analyzes mutation rates and selection pressures in SARS-CoV-2 genomes, identifying elevated G→U and C→U mutations and challenging previous findings on synonymous site selection.

Characterising the epidemic spread of Influenza A/H3N2 within a city through phylogenetics

The paper uses genetic sequence data and patient metadata to analyze local influenza transmission dynamics in Basel, Switzerland, finding that temperature trends correlate with transmission and that elderly and school children drive different transmission networks.

High-resolution influenza mapping of a city reveals socioeconomic determinants of transmission within and between urban quarters

This study maps influenza transmission in a city at high resolution, finding socioeconomic factors like income influence infection patterns and vaccination rates, independent of population density.

Sampling bias and model choice in continuous phylogeography: getting lost on a random walk

The paper compares two phylogeographic models, showing that sampling bias affects Brownian Motion Phylogeography (BMP) and that the spatial Lambda-Fleming-Viot process (LambdaFV) is more robust but applicable to different scenarios.

Ambiguity coding allows accurate inference of evolutionary parameters from alignments in an aggregated state-space

This paper shows how ambiguity coding in alignments allows accurate inference of evolutionary parameters like selection strength and ancestral structures from incomplete data.

Integrated evolutionary and structural analysis reveals xenobiotics and pathogens as the major drivers of mammalian adaptation

The paper combines evolutionary and structural analysis to show that positive selection drives adaptation in immune response and metabolic enzymes.

Modelling structural constraints on protein evolution via side-chain conformational states

The paper develops a structurally-aware substitution model for amino acid sequence evolution by incorporating side-chain conformational states, showing improved performance in divergence time estimation and tree inference.

Oncogenic Notch promotes long-range regulatory interactions within hyperconnected 3D cliques