SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 are Expressed in the Pancreas but are Not Enriched in Islet Endocrine Cells
K. C. Coate, J. Cha, S. Shrestha, W. Wang, L. M. Goncalves, J. Almaca, M. E. Kapp, M. Fasolino, A. Morgan, C. Dai, D. C. Saunders, R. Bottino, R. Aramandla, R. Jenkins, R. Stein, , A. C. Powers
The paper examines ACE2 and TMPRSS2 expression in the human pancreas and finds they are not enriched in islet endocrine cells, suggesting SARS-CoV-2 may not directly infect beta cells through these proteins.
bioRxiv · Aug 31, 2020 · PreprintCell Biology