Author

William D. Keyes

Princeton University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Coleen Tara MurphyiD· 3 shared Rachel L. KaletskyiD· 3 shared Danielle E. MoriD· 2 shared Salman SohrabiiD· 2 shared Alp TarticiiD· 1 shared Gary Wright MilleriD· 1 shared Nicole M. TemplemaniD· 1 shared Vanessa CotaiD· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 26 mutual co-author links

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3 shared papersNeuroscience

Coleen Tara MurphyORCID

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3 papers

Recent·Most cited

High-throughput behavioral screen in C. elegans reveals novel Parkinson disease drug candidates

Salman Sohrabi, Danielle E. Mor, Rachel L. Kaletsky, William D. Keyes, Coleen Tara Murphy

The paper identifies four FDA-approved drugs, including metformin, as potential Parkinson's disease therapeutics using a high-throughput behavioral screen in C. elegans.

Communications Biology · Feb 15, 2021Peer-reviewedNeuroscience

Metabolic defects cause hyperactive mitochondria and Parkinson disease-like traits

Danielle E. Mor, Salman Sohrabi, Rachel L. Kaletsky, William D. Keyes, Alp Tartici, Vrinda Kalia, Gary Wright Miller, Coleen Tara Murphy

This study shows that metabolic defects in C. elegans lead to hyperactive mitochondria and Parkinson's-like traits, with metformin improving motor function and reducing neurodegeneration.

Proceedings of the National Academy of Sciences · Oct 6, 2020Peer-reviewedNeuroscience

CREB non-autonomously regulates Reproductive Aging through Hedgehog/Patched Signalling

Nicole M. Templeman, Vanessa Cota, William D. Keyes, Rachel L. Kaletsky, Coleen Tara Murphy

This paper shows that CREB regulates reproductive aging in C. elegans by controlling a Hedgehog-related signaling factor, WRT-10, through the TGF-β Sma/Mab pathway in the hypodermis.

Developmental Cell · Jun 15, 2020Peer-reviewedDevelopmental Biology