Allele-specific rescue of neurexin behavioral phenotypes by monoamine-targeting compounds
William R Smisko, William R. Haury, Michele Perni, Rebecca Kalik, Jhelaine Palo, Brandon L. Bastien, Jadwiga N. Bilchak, Raheem Khadour, Thomas A. Jongens, Matthew S. Kayser, Michael P. Hart
This study identifies monoamine-targeting compounds that rescue neurexin-related behavioral phenotypes in C. elegans and Drosophila, with olanzapine showing broad efficacy across genetic backgrounds.
bioRxiv · Jul 30, 2026 · PreprintNeuroscience