Michael P. Hart

This study shows that nrx-1 in C. elegans regulates neuropeptide release from cholinergic motor neurons through dense-core vesicle localization and specific isoform function.

This study identifies monoamine-targeting compounds that rescue neurexin-related behavioral phenotypes in C. elegans and Drosophila, with olanzapine showing broad efficacy across genetic backgrounds.

The paper expresses human NRXN1 isoforms in C. elegans to assess their functional impact, finding that some 3' deletion variants cause gain-of-function pathogenicity in behavior.

The paper inserts rare autism variants in C. elegans synaptic genes and assesses their functional impact on behavior, revealing complex effects including loss and gain of function.

This study examines variation in social feeding and bordering behaviors across multiple Caenorhabditis species and finds that behavioral differences do not correlate with evolutionary relatedness.

This paper screens autism-associated genes in C. elegans to identify their impact on GABA neuron remodeling and behavior, revealing distinct developmental trajectories and new molecular mechanisms.

This study identifies conserved autism-associated genes that regulate social feeding behavior in C. elegans through distinct synaptic mechanisms.

The paper shows that the neurexin {gamma} isoform is required for glycerol avoidance in adult C. elegans, while other isoforms are needed in juveniles.

This paper introduces a computational framework to integrate single-cell morphological data with RNA-seq data to uncover genes related to neuronal plasticity.

The paper shows that stress during sexual maturation induces GABAergic neuron remodeling in C. elegans, with differential effects on behavior and molecular mechanisms depending on the stressor and neurexin interactions.