Author

Thomas A. Jongens

University of PennsylvaniaORCID 0000-0002-0190-7339Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Organism:Drosophila· 2 Organism:C. elegans· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Amita SehgaliD· 1 shared Brandon L. BastieniD· 1 shared Folasade A. SofelaiD· 1 shared Jadwiga N. BilchakiD· 1 shared Jhelaine PaloiD· 1 shared Mariela Lopez ValenciaiD· 1 shared Matthew S. KayseriD· 1 shared Michael P. HartiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Amita SehgalORCID

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2 papers

Recent·Most cited

Allele-specific rescue of neurexin behavioral phenotypes by monoamine-targeting compounds

William R Smisko, William R. Haury, Michele Perni, Rebecca Kalik, Jhelaine Palo, Brandon L. Bastien, Jadwiga N. Bilchak, Raheem Khadour, Thomas A. Jongens, Matthew S. Kayser, Michael P. Hart

This study identifies monoamine-targeting compounds that rescue neurexin-related behavioral phenotypes in C. elegans and Drosophila, with olanzapine showing broad efficacy across genetic backgrounds.

bioRxiv · Jul 30, 2026 · PreprintNeuroscience

Effects of Nf1 on sleep behavior are mediated through starvation caused by deficits in SARM1 dependent NAD+ metabolism.

Folasade A. Sofela, Mariela Lopez Valencia, Thomas A. Jongens, Amita Sehgal

This study shows that Nf1 loss in Drosophila causes sleep disturbances via starvation due to metabolic defects linked to SARM1-dependent NAD+ metabolism.

bioRxiv · Sep 14, 2024 · PreprintMolecular Biology