Spatial Biology and Organoid Technologies Reveal a Potential Therapy-Resistant Cancer Stem Cell Population in Pancreatic Ductal Adenocarcinoma
Pritha Adhikary, Jayati L. Chakrabarti, Saptarshi Mallick, Xi Sun, Ugonna Ezuma-Igwe, Abigail G. Branch, Jiang Wang, Nicolas Braissand, Megan P. Corbett, Sangmin Kim, Rohan Kanakamedala, Willian C. Bastian, Eugene Douglass, Meenu Priya Resmi, Payton D. Stevens, , Yana L. Zavros
The paper uses spatial imaging and organoid models to identify therapy-resistant CD44v9+ cancer stem cells in PDAC and show that cabozantinib may enhance immunotherapy by altering the tumor microenvironment.
bioRxiv · May 22, 2025 · PreprintCancer Biology