Actin dysregulation induces immune evasion via oxidative stress-activated PD-L1 in gastric cancer
Yoojeong Seo, Jinho Jang, Kyung-Pil Ko, Gengyi Zou, Yuanjian Huang, Shengzhe Zhang, Jie Zhang, Sohee Jun, Wonhong Chu, Vishwa Venkatesan, Sanjana Dhakshinamoorthy, Jae‐Il Park
This study shows that CRACD inactivation in gastric cancer leads to immune evasion via oxidative stress-activated PD-L1, suggesting HIF1 and PD-L1 as therapeutic targets.
bioRxiv · Dec 18, 2024 · PreprintCancer Biology