X. Chen

This paper introduces a tumor-specific causal inference framework to identify causative somatic genome alterations and their impact on molecular phenotypes in individual tumors.

This paper investigates the sequence diversity and evolutionary patterns of the fhuA gene in Salmonella and Escherichia, revealing unique clustering and mutation patterns that suggest gene recombination and selection pressure.

This study analyzes 255 chronic osteomyelitis patients in northern China, finding higher prevalence in males aged 41-50, common infection sites, and better outcomes with two-stage debridement and antibiotic-loaded PMMA beads.

The paper identifies YrlA RNAs as tRNA mimics in bacteria, showing structural similarities to tRNAs but with key differences.

The paper shows that miR1510 in Phaseoleae species is primarily a 22 nt isoform due to monouridylation, and demonstrates how post-processing modifications can optimize miRNA function.

This study shows that targeting the HIV-1 fusion peptide with specific immunogens induces cross-clade neutralizing antibodies in animals.

This study identifies WDR45's role in neurodegeneration by showing its regulation of ER homeostasis and neuronal death through autophagy defects.

This study identifies LINC00844 as an androgen-regulated lncRNA that suppresses prostate cancer migration and invasion by modulating AR chromatin binding and NDRG1 expression.

This study identifies XBP1 target genes and shows the IRE1a-XBP1 pathway resolves secretory stress and promotes Th2 cell proliferation and cytokine regulation.

This study demonstrates that Nano-DOX-loaded TAM can reprogram GBM cells to an anti-GBM phenotype through DAMP emission, enhancing immune response and reducing tumor growth.

This study identifies lysine fatty acylation as a regulatory mechanism for K-Ras4a, showing that SIRT2-mediated defatty-acylation promotes oncogenic activity by enhancing endomembrane localization and interaction with A-Raf.

The paper examines how gene expression variability across cells and species influences innate immune responses, finding that rapidly diverging genes show high variability while regulatory genes are conserved.

The paper shows that some Arabidopsis accessions grow larger rosettes under zinc deficiency due to delayed flowering, which prolongs vegetative growth.

The paper presents a programmable optical stimulator for Drosophila eyes that induces retinal degeneration using blue light, showing it can reliably create environmental ocular stress.