Author

J. Pramanik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

B. Mahata· 5 shared S. A. Teichmann· 5 shared G. Kar· 4 shared X. Chen· 4 shared A. Riedel· 2 shared A.-C. Gavin· 2 shared J. D. Shields· 2 shared J. Henriksson· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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5 shared papersImmunology

B. Mahata

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

CLICK-chemoproteomics and molecular dynamics simulation reveals pregnenolone targets and their binding conformations in Th2 cells

S. Roy, S. Roy, B. Mahata, J. Pramanik, M. L. Hennrich, A.-C. Gavin, S. A. Teichmann

The paper identifies pregnenolone targets and their binding conformations in Th2 cells using chemoproteomics and molecular dynamics simulations.

bioRxiv · May 23, 2023Immunology

Rora regulates activated T helper cells during inflammation

V. Liora, J. A. Walker, J. Henriksson, Z. Miao, E. Natan, G. Kar, S. Clare, J. L. Barlow, E. Charidemou, L. Mamanova, X. Chen, V. Proserpio, J. Pramanik, S. Woodhouse, A. V. Protasio, , S. A. Teichmann

This study investigates Rora's role in CD4+ T cells during inflammation, finding it regulates lung inflammation and is controlled by IL-33 and CCL7.

bioRxiv · Jul 15, 2020 · PreprintImmunology

Tumors induce de novo steroid biosynthesis in T cells to evade immunity

B. Mahata, J. Pramanik, L. v. d. Weyden, K. Polanski, G. Kar, A. Riedel, X. Chen, N. A. Fonseca, K. Kundu, L. S. Campos, E. Ryder, G. Duddy, I. Walczak, K. Okkenhaug, D. J. Adams, , S. A. Teichmann

This study shows tumors induce steroid synthesis in T cells to evade immunity, and blocking this pathway restores anti-tumor immunity in mouse models.

bioRxiv · Jun 14, 2020Immunology

CLICK-enabled analogues reveal pregnenolone interactomes in cancer and immune cells

S. Roy, J. Sipthorp, B. Mahata, J. Pramanik, M. L. Hennrich, A.-C. Gavin, S. V. Ley, S. Teichmann

The paper maps pregnenolone interactomes in cancer and immune cells using chemical biology and chemoproteomics to identify proteins involved in its trafficking and non-genomic actions.

bioRxiv · Oct 16, 2019Biochemistry

Single-cell RNA sequencing reveals a dynamic stromal niche within the evolving tumour microenvironment

S. Davidson, M. Efremova, A. Riedel, B. Mahata, J. Pramanik, J. Huuhtanen, G. Kar, R. Vento-Tormo, T. Hagai, X. Chen, M. A. Haniffa, J. D. Shields, S. A. Teichmann

This study uses single-cell RNA sequencing to analyze stromal cell changes in murine melanoma, identifying distinct CAF populations and their roles in immune suppression across tumor development.

bioRxiv · Nov 9, 2018 · PreprintCancer Biology

The IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

J. Pramanik, X. Chen, G. Kar, T. Gomes, J. Henriksson, Z. Miao, K. Natarajan, A. N. J. McKenzie, B. Mahata, S. A. Teichmann

This study identifies XBP1 target genes and shows the IRE1a-XBP1 pathway resolves secretory stress and promotes Th2 cell proliferation and cytokine regulation.

bioRxiv · Dec 15, 2017Cell Biology